What is Connection Map in Data Visualization? 4, 324333 (2020). Dr. Huang taught General Chemistry, Quantitative Analysis, and Instrumental Methods for eight years at . I have an undergraduate degree in pharmacology from the University of Toronto. PubMed Central DNA analysis of an early modern human from Tianyuan Cave, China. Compared with the genetic diversity observed among all analysed Gravettian-associated groups, Epigravettian-associated individuals show significantly lower amounts of genetic diversity (two-tailed t-test, P<0.001) (Fig. Piezonka, H. et al. The inferred topology reveals a phylogeographic pattern irrespective of individual ages. Furthermore, the gene pool of the western Gravettian populations is found continuously for at least 20,000 years: their descendants who are associated with the Solutrean and Magdalenian cultures stayed in southwestern Europe during the coldest period of the last Ice Age (between 25,000 and 19,000 years ago) and later spread north-eastward to the rest of Europe. Wonderful course so far Tina. Genetic sexing revealed 78 maleindividuals and 38 femaleindividuals (Supplementary Fig. 26 and Supplementary Data 2.H). Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia. The sex of each individual was determined by the ratio of sequencing coverages on sex chromosomes versus autosomes (Supplementary Data 1.C). The code for the newly developed ROH based contamination estimate method is available at https://github.com/hyl317/hapROH. TV Actress. About me. (eds. Track your course progress, set daily goals, and make success a routine. National Science Council feb. 2009 - feb. 2009 1 maand. Itchy Eyes and a Runny Nose? An improved, lightweight and secure authentication scheme in context of fog-centric IoT communication is proposed in this paper to eradicate all the above mentioned security shortfalls of Wajid et al scheme. & Dolukhanov, P.) 122145 (Avebury, 1993). Int. No, there are no prerequisites for enrolling. PubMed For ds_halfUDG libraries, we masked 2bp from both ends of the reads with trimBam in bamUtil 1.0.13 (https://github.com/statgen/bamUtil) to remove the damaged sites. What is surprising is that the Code Cup was so popular that Stanford decided to throw open a Data Science Week in which anyone can submit a code challenge to the top 200 submissions. In central Europe, admixture with ANF ancestry became highly common but not ubiquitous, indicating the co-existence of hunter-gatherer and farmer societies without admixing for several hundred years. The generation time is set to 29 years and the error bars show the SE of the admixture date estimated from jackknife resampling (n=22 autosomal chromosomes). Y.H. Sign up below if you'd like to join a growing community that is enthusiastic about learning and improving their lives. In this case, the data is being loaded from the MySQL database. Evol. The incoming Villabruna ancestry later became the most widespread hunter-gatherer ancestry across Europe. Claim Author Page. Purchasing this course makes it your own. We also genotyped a selection of previously published individuals with the same approach (Supplementary Data 1.G)2,4,30,74,75,76,77,78. University Universit Chouaib Doukkali; . I have an undergraduate degree in . All Rights Reserved. Tina Huang is a Data Scientist at a FAANG (Facebook, Amazon Apple, Netflix, Google) company. 2a). Individuals with libraries showing signs of contamination were further tested using PMD-filtered bam files. 1517). Along with pushing for more accessibility, she also creates content around working in the tech industry, the challenges that come with it, and career advice. Tinas authentic and engaging delivery style allows her to create original content on topics like how to be more productive, how to learn more efficiently, how to land a job in data science, and more. Laplace, G. Essai de Typologie Systmatique (Annali dellUniversit di Ferrara, 1964). Lcuyer, C., Hillaire-Marcel, C., Burke, A., Julien, M. A. The genetic affinity to the Villabruna ancestry is present in El Mirn and in Magdalenian-associated individuals from western and central Europe. Kozowski, J. K. The origin of the Gravettian. 5 and Supplementary Information, section9). Great explanations and feels like real interviews that helps me warm up myself before the real interview! Its mainly used in industries such as finance, insurance, healthcare, and insurance-related apps such as credit card applications, vehicle purchasing, etc. All Rights Reserved. 1c) and a west Eurasian principal component analysis (PCA) (Extended Data Fig. Reimer, P. J. et al. A dashed line of 50 cM total ROH is drawn in each panel to help comparison between panels with different y-axis scales. Seguin-Orlando, A. et al. Most data scientists are used to having to do the dirty work of cleaning and cleansing data. The tool qpAdm 810 in ADMIXTOOLS 5.1 was applied to model the ancestries of admixed populations, with allsnps mode and the outgroup set selection described in Supplementary Information, section11. Nature 514, 445449 (2014). Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers, https://doi.org/10.1038/s41586-023-05726-0. ContamLD: estimation of ancient nuclear DNA contamination using breakdown of linkage disequilibrium. Check out The data science resume that got me my FAANG job and subscribe to Tina Huangs YouTube channel. Additional details are provided in SupplementaryInformation, section11 and SupplementaryTable 3. Big Data, Data Mining, and Machine Learning (Jared Dean) . This provides further support for the model with no long-term decline of genome-wide Neanderthal ancestry in modern humans following their introgression18. The sequence alignment/map format and SAMtools. Huang's parents immigrated to New York City where her two older brothers . 3b). Patterson, N. et al. Brunel, S. et al. Science 365, eaat7487 (2019). 5, 820825 (2021). Besides El Mirn, who has around 43% Villabruna ancestry, all other Magdalenian-associated individuals have a lower proportion of this component (1929%) and can thus be assigned to the GoyetQ2 cluster (Fig. H. Rougier received support from the College of Social and Behavioral Sciences of CSUN and the CSUN Competition for RSCA Awards. Become an in-demand #DataScience professional TODAY with the 365 Data Science Program -> https://365datascience.com, analyzing similar products to compare how they performed, data visualizations with SQL and Python or R. Max Planck Institute for Evolutionary Anthropology. Hi friends! Sci. Required fields are marked *. Edit your profile. 1 and 2). I worked in bioinformatics in cancer research and then decided to a masters in computer science (MCIT) from the University of . 25, 459466 (2015). Wow! In no time, she established herself as one of the favorite vloggers of the data community. In this period, the Oberkassel-ancestry admixture spread further east, reaching Samara by around 6.5ka, and an increase in Sidelkino ancestry was detected in hunter-gatherers from the Baltic region, which was previously associated with the transition from the Narva culture to the Comb Ceramic culture38,39 (Extended Data Fig. Publishers note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Extended Data Fig. Connect with them: Email: hellotinah@gmail.com. & Steinrcken, M. Parental relatedness through time revealed by runs of homozygosity in ancient DNA. Notably, and contrary to the report by Fu et al.4, another Gravettian-associated population from centralwestern Europe (Goyet in Belgium, n=6 individuals) is both geographically and genetically intermediate between the Vstonice and Fournol clusters. She has been working for the data sciences industry since 2014. 1a, and the y-axes report time in thousand years before present (kBP). Science 358, 659662 (2017). C. Posth, H.Y., A.G., A.B.R., W.H. BMC Res. A negative and cave bear positive controls were included. Tina Huang. Therefore, contrary to previous suggestions34, this demonstrates that the post-LGM diffusion of the Magdalenian was indeed associated with northward and northeastward population expansions from western Europe35. The libraries underwent shallow shotgun sequencing on an Illumina HiSeq 4000 instrument with 75 single-end-run cycles using the manufacturers protocol, to evaluate the human endogenous DNA content and quality. Check out Do Deepfakes Have Fingerprints? 41 Year Olds. b, Population diversity shown by PMR between individuals in different groups. However, its formation, diffusion and interaction with contemporaneous hunter-gatherers from eastern Europe and their interplay with later expansions of Neolithic farmers from southeastern Europe are not well characterized. I love learning new things a. Cuando se ampla, se proporciona una lista de opciones de bsqueda para que los resultados coincidan con la seleccin actual. In this admixture graph, the lineage related to Zlat k splits more basally than the Bacho Kiro IUP group, who contributes to Tianyuan, UstIshim and Goyet Q116-1 (indicated with red lines), but not to the Sunghir group. Natl Acad. Mounier, A. et al. All individuals belonging to the Fournol cluster show higher affinity to Goyet Q116-1 than to the Sunghir group (n=4), and the Vstonice-cluster individuals show higher affinity to the Sunghir group than to Goyet Q116-1 (Extended Data Fig. Shes currently at Microsoft. Evol. 13, 24472461 (2018). A software engineer who now works as a content creator full-time, Mayuko Inoue runs a YouTube channel dedicated to software engineering, working in the tech industry, and life in general. In particular, the 13ka Pradis 1 individual from northeastern Italy represents the most basal lineage compared to all other Epigravettian-associated individuals, including the older Tagliente 2 and Villabruna genomes from northern Italy (group 1). Internet Explorer). 211 and Supplementary Table 1). 10 and 11). Data warehousing is a field where you often have to deal with a lot of raw data. This channel is about data science, learning, and productivity. www.sciencedaily.com/releases/2023/03/230301120846.htm (accessed March 4, 2023). Sci. This might have been in part triggered by the concomitant expansion of Neolithic farmers across Europe and/or by environmental factors, such as the climatic event around 8.2ka, the largest abrupt cooling in the northern hemisphere during the Holocene epoch46,47. Prfer, K. et al. The ROH segments in hunter-gatherer genomes were identified using hapROH101. The x-axes report the geographic regions as divided in Fig. mtDNA capture63 was also performed for those libraries where mtDNA coverage was not high enough to assess mtDNA haplogroup and contamination. As she gains working experience with one of the FAANG companies, Tina continues to share interesting details about her career journey with the audience. Follow Author. A user manual including an installation guide is available at https://haproh.readthedocs.io/en/latest/hapROH_with_contamination.html. Bortolini, E. et al. If you want to know more, you can always go to MySQLs data warehouse site. 803147-RESOLUTION (to S.T. Other individuals from that period, such as Zlat k from Czechia and UstIshim from Russia, do not carry significantly more Neanderthal ancestry than other non-African groups1,7, indicating differential interactions between Neanderthals and early modern humans during their initial expansions across Eurasia. Max Planck Institute for Evolutionary Anthropology. Look here to get updated on my recent favourite books, animes, filming equipment and more! 9; the entire IT and laboratory teams at the Department of Archaeogenetics of MPI-SHH for technical assistance; M. Meyer and S. Nagel for support with single-stranded library preparation; K. Post, P. van Es, J. Glimmerveen, M. Medendorp, M. Sier, S. Dikstra, M. Dikstra, R. van Eerden, D. Duineveld and A. Hoekman for providing access to human specimens from the North Sea (The Netherlands); M. D. Garralda and A. Estalrrich for providing access to human specimens from La Riera (Spain); J. Grski andM. Zajcfor providingaccess tohuman specimensfromMaszycka cave;C. Di Patti for providing access to human specimens from San Teodoro 2 (Italy); P. Blaeviius for providing access to the Donkalnis human remains and the new radiocarbon dates; the Italian Ministry of Culture and Soprintendenza Archeologia Belle Arti e Paesaggio for the Provinces of Verona, Rovigo, and Vicenza for granting access to the human remains of Tagliente 2; F. Fontana, who carries out investigations of the Riparo Tagliente site (Italy); the Friuli Venezia Giulia Superintendency for providing access to the human tooth Pradis 1; and the Soprintendenza Archeologia Belle Arti e Paesaggio for the Provinces of Barletta-Andria-Trani and Foggia for providing access to the Paglicci human remains. Bioinformatics 38, 37683777 (2022). Third, Magdalenian-associated individuals not only from Iberia but also from the rest of Europe carry Epigravettian-associated ancestry (Villabruna cluster). ), no. This results in a tree with 57 newly reported and previously published ancient individuals while present-day sequences are collapsed in the major Y-chromosome haplogroups (the most basal lineages are not shown). The version used for this work is archived at https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF. You'll likely won't meet her on a day to day basis, but she's always lurking in the Discord and following everybody's progress (not . Within the pipeline, the adapters were removed by AdapterRemoval 2.2.065, reads were mapped with BWA 0.7.12 aln/samse algorithm66, duplications were removed by DeDup 0.12.1 (https://github.com/apeltzer/DeDup) and damage patterns of each library were checked with mapDamage 2.0.6 and 2.0.967. Hi, my name is Tina and I'm a data scientist at a FAANG company. In other cases, you may have to create a more complex database structure (such as SQLite). 132, Tables 14 and references. At the same time, these two groups started mixing with each other, and continued to do so for around 3,000 years," Krause says. The membrane was able to achieve FRR of 98.73 0.83 % after 4 cycles of filtration, indicating that anti-fouling properties have been enhanced. Ecol. Her motto to live by is "Always minimize effort and maximize outcome!". 6 West Eurasian PCA showing the genetic positioning of post-LGM hunter-gatherers. Riddle Solved: Why Was Roman Concrete So Durable? Rivollat, M. et al. Lazaridis, I. et al. A dynastic elite in monumental Neolithic society. Genome Res. Other proposed climatic refugia for human survival during this period are the Italian peninsula, the Balkans and the southeastern European Plain, but the actual genetic contribution of populations from these regions to post-LGM Europeans is highly debated11,12,13. Xiamen Guansheng Precision Machinery Co Ltd is a company integrating R&D, production and sales. Catalano, G. et al. of estimates from 5-cM-block jackknife analysis. The Kostenki genetic signature (related to the Kostenki 14 genome, and hereafter referred to as the Kostenkicluster or ancestry) contributed to the later Vstonice genetic cluster(hereafter,Vstonice cluster or ancestry), named after the Doln Vstonice site in Czechia4. Sci. Wood, R. E. et al. Ecol. Thisancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutreanculture, and withthe following Magdalenian culturethat re-expanded northeastward after the Last Glacial Maximum. Substantially contaminated libraries as well as marginally contaminated libraries of individually analysed genomes were filtered to maintain reads showing postmortem DNA damage (Methods and Supplementary Figs. Folding bicycle. 2022 Fab Business Solutions - All Rights Reserved. Proc. "With these findings, we can for the first time directly support the hypothesis that during the Last Glacial Maximum people found refuge in the climatically more favourable region of southwestern Europe" says first author Cosimo Posth. My name is Tina Huang and I'm a data scientist at a FAANG company. Science 363, 12301234 (2019). For ds_halfUDG libraries, we called genotypes on all targeted sites from 2bp-masked bam files; for ds_nonUDG libraries, we called genotypes on transversion sites only; for ss_nonUDG libraries, we called genotypes with single-strand mode, which ignores forward reads at C/T polymorphisms and reverse reads at G/A polymorphisms. We did not correct the calibrated dates for marine or freshwater reservoir effects but, when available, we report individual stable isotope values (15N/13C and C:N ratio) in Supplementary Data 1.A to evaluate the potential impact of such reservoir effects. Tina Huang. use of cookies Trzej niedwiedzi braciszkowie przeywaj swoje dziecistwo, pakujc si w najrozmaitsze tarapaty za spraw magicznego pudeka. Taiwan. The mtDNA contamination was estimated by Schmutzi (--notusepredC --uselength)69 for all the libraries. You probably remember me from class or an event, and that's why this profile is so interesting - it traces my journey from student-athlete at the University of California Davis into a successful entrepreneur with multiple ventures under her belt by age 25, Your email address will not be published. b, Calibrated radiocarbon dates of individuals plotted in a. After merging, individuals with less than 6,000 SNPs on 1240k sites were excluded from further analysis because of low coverage. She supports Propel on the business and marketing side. PubMed The end goal is to create and grow a product that users love. Biol. The latter was created as a support network for women in the industry to discuss, share, and learn from each other.. Biol. 2 The distribution of mtDNA and Y-chromosome haplogroups among different hunter-gatherer groups. van de Loosdrecht, M. et al. Extended Data Fig. 18 and Supplementary Data 2.O), suggests the Balkans as a source of the incoming Epigravettian-associated population. Nucleic Acids Res. Admixture graphs were reconstructed using qpGraph 6450, with allsnps mode to correct for low-coverage sample and Mbuti.DG set as the outgroup. The grouping of Epigravettian-associated populations is shown with the same colour in a. & Nielsen, R. ANGSD: analysis of next generation sequencing data. One of the best-known and most liked personalities in the data community, Tina is a successful YouTuber and works with one of the FAANG companies. The neighbour-joining tree was then reconstructed using the neighbour-joining method implemented in Ape 5.3 package104 of R 3.5.1. There is no biographical data to display. By co-analysing previously published data with our newly reported genomes associated with the Magdalenian from La Marche (18ka) and Pincevent (15ka) in western and northern France, respectively, and Maszycka (1816ka) in southern Poland, we confirm that the Goyet Q116-1 ancestry survived in all studied Magdalenian-associated genomes besides in Gravettian and Solutrean-associated individuals from southwestern and western Europe (Fig. 359, 318 (2015). Libraries showing a mitochondrial or nuclear contamination rate over 10% were considered substantially contaminated whereas those between 5 and 10% were considered marginally contaminated and were treated differently (details are provided in Supplementary Information, section3). - Technical researcher and data analyst under the supervision of Dr. A. Meyer and Dr. S. Bae at UCLA. PubMed Central Ice Age survivors. Genetics and material culture support repeated expansions into Paleolithic Eurasia from a population hub out of Africa. By submitting a comment you agree to abide by our Terms and Community Guidelines. Culturally, however, we see both widespread general tendencies, such as weaponry and some portable art48, and other aspects that have a more regional character, such as mortuary practices (Supplementary Information, section13), various originalities in lithic and hard organic materials tool kits and adornments20,21. The emergence of hunter-gatherer pottery in the Urals and West Siberia: new dating and stable isotope evidence. You need more data until you have the right ingredients to make a good recipe, but you also need less data until you have the right amount of ingredients to make a bad recipe. This is further validated by f4-statistics of the form f4(Mbuti, Arene Candide 16; Goyet Q-2, Magdalenian-associated individuals), which is significantly positive only for El Mirn, whereas all other tested individuals and Goyet Q-2 are symmetrically related with respect to Arene Candide 16 (Supplementary Fig. In no time, she established herself as one of the favorite vloggers of the data community. The suspension was then centrifuged and transferred into a binding buffer as previously described56. Commun. Note: Content may be edited for style and length. In spite of growing discussions about its nature27,28, the Epigravettian culture has been traditionally assumed to be the result of a transition from the preceding local Gravettian29. Nature 555, 197203 (2018). And if youre new to data science, check out the 365 Intro to Data and Data Science course. Biol. I also have a newsletter called Boop's Keyboard! In this video, I had the opportunity to talk with Tina Huang, a Data Scientist at one of the FAANG companies. Genomic diversity and admixture differs for stone-age Scandinavian foragers and farmers. Publication: Huang T, Reimand J. Network-rewiring mutation in kinase signaling networks are informative of cancer patient. 1) we used MUSCLE (-maxiters 2)96 to create a multiple genome alignment of previously published sequences and newly reported mtDNA consensus sequences with q20 according to defined thresholds (minimum average coverage >5-fold, contamination estimate <20%, HaploGrep2 haplogroup assignment consistent with manual assignment). Palma di Cesnola, A. Error bars show 1s.e.m. Graduate - February 2015 to September 2015. Is a data scientist at one of the world's largest tech companies (she keeps the firm anonymous so she can publish more freely). is supported by a Ramn y Cajal fellowship (RYC-2017-22558). Anti Slip Coating UAE 4). The 3 Greatest Moments in science library uga hours History, Addicted to hills science diet adult small bites? Limits of long-term selection against Neandertal introgression. Negative and positive controls were carried alongside each experiment. Biol. The resulting GoyetQ2 cluster includes individuals spanning from western France to Poland in the period between 18 and 15ka. Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe. Google Scholar. We love meeting interesting people and making new friends. 27 and 28). This suggests that between the Early/Middle and Late Gravettian there was an east-to-west expansion of the Vstonice-associated ancestry that reached central-western Europe and created a longitudinal admixturecline between those two genetically distinct pre-LGM populations. I am super excited to join the 365 Data Use Cases series, and in this post, I will share insights about my favorite data use case: product development. Sci. Tina Huang. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness . Vallini, L. et al. 412, 3743 (2016). The x-axis shows the average age of each tested individual/group and the y-axis shows the proportion of Sidelkino ancestry, relative to the total hunter-gatherer ancestry (Oberkassel + Sidelkino) in each group. Sci. Nucleic Acids Res. "Further interdisciplinary research will clarify which exact processes were responsible for the genetic replacements of entire Ice Age populations.". For phylogenetic reconstruction (Extended Data Fig. Korlevi, P. et al. Hajdinjak, M. et al. It requires countless decisions to get them right, many of which have not been as straightforward at first. 537, 2432 (2020). October 28 Actress #31. Protoc. Citations 52. Materials provided by Max Planck Institute for Evolutionary Anthropology. Front. We can have either structured data (e.g. Tina started her YouTube channel in 2020. 10, 552010 (2019). . We applied ANGSD 0.93470 and hapCon71 for libraries from male individuals, and applied contamLD72 and a newly developed method that analyses contamination in ROH for female and male libraries (see Supplementary Information, section2 for a detailed description).
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